Daniel Penello, M.D.

Dr. Daniel Penello specializes in complicated disorders of the hand, wrist and elbow and is fellowship-trained in Hand, Wrist, Elbow and Upper Extremity surgery.

headshot of Daniel Penello, M.D., M.B.A.

Doctor of Medicine

University of Toronto

Residency

University of Toronto

Fellowship

Cleveland Clinic Combined Hand & Upper Extremity Fellowship

Bio

Dr. Daniel Penello has been serving the Tampa Bay community for over a decade. He is board-certified by The American Board of Orthopaedic Surgery.

Dr. Penello graduated Summa Cum Laude with a Bachelor of Science in Kinesiology at York University in Toronto, Canada. He earned his medical degree from The University of Toronto with honors in 2002. He was admitted to the esteemed Alpha Omega Alpha Honor Medical Society. He then completed his Orthopaedic Surgery Residency at The University of Toronto where he was recognized for his academic achievement and teaching ability. Throughout his training and career, Dr. Penello has received several awards for outstanding performance, and Humanitarianism. His ability to successfully treat complex conditions using leading-edge techniques and state-of-the-art technology garnered him recognition as Top Doctor in 2012 and 2020 for Surgery of the Hands and Upper Extremities.

His dedication to health policy, process improvement and commercialization of medical devices led him to receive a Health Sector MBA at The Rotman School of Management in Toronto during his residency. He then completed a Hand and Upper Extremity Fellowship at The Cleveland Clinic Foundation, in Cleveland, Ohio.

Dr. Penello has been involved with numerous research projects. He has also authored and co-authored publications in the United States and Canada.

With a strong desire to help the community, Dr. Penello and his family are strong supporters of many local charitable organizations including The Kind Mouse, Alpha House and Johns Hopkins All Children’s Hospital.


Findatopdoc Top Doctor Badge

News & Articles

St. Pete doctor implants first 3-D printed bone into man's finger

Fox 13 News, August 2019

Surgeon implants first custom 3D-printed finger bone in the US

Tampa Bay Patch, July 2019

Why to keep an eye on 3D-printing, robotics & regenerative medicine in orthopedics

Becker’s Spine Review, February, 2019

What Our Patients Are Saying

  • I had carpal tunnel on both hands .. he did a fantastic work with surgeries .! Very nice and kind person too .

    philippe guillot
    January 22, 2026

    Dr.Penello Oh my goodness, I have no more pain... He placed the needle perfectly. Dr.Penello is not only handsome, but very, very smart. I'm so glad I went to him. I wake up in the morning now with no pain in my right hand I could just cry tears of joy instead of tears of pain. I love this Dr..........very professional I could tell he genuinely cared, unlike other Drs, if you want to know... read more

    sandta
    May 1, 2025

    Dr. Penello was excellent. My surgery was successful and he personally followed up with me via phone to make sure I was feeling ok. At my follow up appointment post surgery he took the time to explain all the details of the surgery and answered all of my questions without hesitation. He was very involved start to finish and is a genuinely pleasant person. I highly recommend him for any orthopedic needs.

    Colleen Glenn
    August 28, 2023
  • Dr. Penello is one of the best doctors I have ever been. He is kind and caring, he listens to your pain, to the level of pain you are at, he reads the XRays and MRIs to you in great detail just so you know what he is explaining and he explains everything in details and he doesn’t condemn you for asking a bunch of questions which I do! Coming from a medical family, mom... read more

    Cristina Alves
    July 2, 2024

    Dr. Penello is fantastic! I saw him for a second opinion for my wrist fracture and he had me in surgery the next day. He is skilled, knowledgeable, personable, and should be your first choice for wrist/hand injuries. I can't say enough good things about him, the staff, and my experience at Alexander Orthopedics!

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    Tonya Olson
    October 12, 2020

    My right fingers were severely deformed from rheumatoid arthritis. They looked like ancient limbs of an oak tree. After two very successful surgeries, Dr Panello was able to straightened them. My fingers are absolutely beautiful and functional. He actually did the impossible, when several hand surgeons just shook their heads and sent me to hand therapy instead. I cannot thank Dr Penello enough for his expertise, his fantastic bedside manner, sense of humor and empathy.... read more

    Holly Harper
    March 7, 2023
  • I cannot say enough good things about Dr. Penello. I am just recovering from my second hand surgery and will say that both went so smoothly. Rather than the experiences being unsettling or anxiety-producing, they were as pleasant as can be under the circumstances. Dr. Penello is a friendly and caring doctor with a wonderful bedside manner which gives you a sense of trust in him. And it is well earned. ... read more

    Terri Rick
    February 10, 2023

    Dr. Penello reattached my bicep to the bone after I tore it off. He did an excellent job and now 10 years later it is still in great shape. Saw his wonderful PA this week, to confirm the VA was wrong, and it was a very informative and delightful visit. I found he has an excellent PA assisting him.

    Michael Seel
    December 22, 2023

    I can only surmise that the one star reviews, one without any comment attached and one illustrating a possible case of “lost in translation”, were submitted for no good reason. I lived in a foreign country whose language I was not conversant in and experienced many difficulties understanding and being understood. Because of them, I feel I must speak out about my positive experience. Dr. Penello operated on both my hands and has given me back... read more

    Christine Bush
    December 5, 2019